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Article

HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome

1 Jan 2019

Abstract excerpt

Rationale: Hepatitis B virus (HBV) is a leading cause of liver diseases. HBV covalently closed circular DNA (cccDNA) is a critical obstacle of complete elimination by anti-HBV therapy. HBV cccDNA accumulates in nucleus as a chromatin-like cccDNA minichromosome assembled by histones and non-histones. However, the underlying mechanism of modulation of cccDNA minichromosome in hepatocytes is poorly understood....

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Identifiers

PMID: 31695772
DOI: 10.7150/thno.37173

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