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Article

Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.

Nature - 1 Aug 2024

Kim Elizabeth D, Wu Xiaoan, Lee Sangyun, Tibbs Gareth R, Cunningham Kevin P, Di Zanni Eleonora, Perez Marta E, Goldstein Peter A, Accardi Alessio, Larsson H Peter, Nimigean Crina M

Abstract excerpt

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels1 are essential for pacemaking activity and neural signalling2,3. Drugs inhibiting HCN1 are promising candidates for management of neuropathic pain4 and epileptic seizures5. The general anaesthetic propofol (2,6-di-iso-propylphenol) is a known HCN1 allosteric inhibitor6 with unknown structural basis. Here, using single-particle cryo-electron...

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Source

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Identifiers

PMID: 39085604
DOI: 10.1038/s41586-024-07743-z
PMCID: PMC11634041

Genes

HCN1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants.PMID 39085604Read ↗

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Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation.Semantic proximity Read ↗

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Targeting the voltage sensor of Kv7.2 voltage-gated K+ channels with a new gating-modifier.Semantic proximity Read ↗

Similar voltage-sensor movement in spHCN channels can cause closing, opening, or inactivation.Semantic proximity Read ↗

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