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Article

No dose-dependence of DNA double-strand break misrejoining following α-particle irradiation

1 Jan 2000

Abstract excerpt

PURPOSE: To investigate whether an explanation for the high effectiveness of densely ionizing radiation with regard to complex biological endpoints can be derived from measurements of radiation-induced double-strand break (DSB) misrejoining. MATERIALS AND METHODS: Misrejoining of radiation-induced DSB in normal human fibroblasts was determined by comparing hybridization analysis of large restriction fragments as...

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PMID: 10923613
DOI: 10.1080/09553000050050909

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