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Article

Influence of the culture time on DNA damage and repair in isolated rat hepatocytes exposed to nitrochlorobenzene derivatives.

Mutation research - 1 Jan 2000

Cesarone C F, Fugassa E, Gallo G, Voci A, Orunesu M

Abstract excerpt

The induction of DNA damage on 1.5- and 24-h cultured hepatocytes was tested after a 3-h exposure to 5 and 50 microM mono-, di-, and trinitrochlorobenzene (100-00-5; 97-00-7; 88-88-0). DNA-repair synthesis, elicited by nitrochlorobenzene treatment, was also estimated 24 and 48 h after the withdrawal of the nitro-aryl halides. DNA damage and repair were evaluated by determining the DNA elution rate in alkali. A...

Topics

Animals
Cell Survival
Cells, Cultured
DNA
DNA Repair
Dimethylnitrosamine
Dinitrochlorobenzene
Liver
Methyl Methanesulfonate
Mutation
Nitrobenzenes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Picryl Chloride

Rats

Time Factors

Source

Identifiers

PMID: 6738566
DOI: 10.1016/0167-8817(84)90028-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-6738566-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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