Article
Sequential monitoring of cytogenetic damage in rat lymphocytes following in vivo exposure to aflatoxin B1 and N-nitrosophenacetin.
Mutation research - 1 Nov 1990
Li S Y, Lin J K
Abstract excerpt
Rats were treated intraperitoneally with different concentrations of aflatoxin B1 (AFB1) or N-nitrosophenacetin (NP). Blood was sequentially drawn by venous puncture at 6, 24, 72, 120 h and 14 days after a single injection of AFB1 or NP. After AFB1 the frequency of SCEs and chromosome aberrations increased progressively and reached a maximum level after 24 h and then decreased with time. By 2 weeks post...
Topics
- Aflatoxin B1
- Aflatoxins
- Animals
- Cells, Cultured
- Chromosome Aberrations
- Male
- Mutation
- Nitrosamines
- Rats
- Rats, Inbred Strains
- Sister Chromatid Exchange
