A comparison of the 8-hydroxydeoxyguanosine and micronucleus techniques for the assessment of X-ray and UV induced genotoxicity.

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Article

A comparison of the 8-hydroxydeoxyguanosine and micronucleus techniques for the assessment of X-ray and UV induced genotoxicity.

Research communications in chemical pathology and pharmacology - 1 May 1993

Kobus K, Turner J, Priestley B, Dreosti I

Abstract excerpt

A comparison was made of the relative sensitivities of the cytokinesis-block micronucleus and the 8-hydroxydeoxyguanosine assays for the assessment of X-ray and UV-induced genotoxicity in mouse splenocytes in vitro. A detectable (p < 0.05) increase in micronuclei occurred at about 1/5 the X-ray exposure required to induce a significant increase in the level of 8-hydroxydeoxyguanosine. With UV radiation a...

Topics

8-Hydroxy-2'-Deoxyguanosine
Animals
Cells, Cultured
Deoxyguanosine
Mice
Micronuclei, Chromosome-Defective
Micronucleus Tests
Mutagenicity Tests
Mutation
Spleen
Ultraviolet Rays
X-Rays

Source

Open in PubMed

Identifiers

PMID: 8321925

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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