Article
Insights into the pathogenesis and pathogenicity of cerebral amyloid angiopathy.
Frontiers in bioscience (Landmark edition) - 1 Jan 2009
Love Seth, Miners Scott, Palmer Jen, Chalmers Katy, Kehoe Patrick
Abstract excerpt
Amyloid-beta (Abeta) cerebral amyloid angiopathy (CAA) affects most Alzheimer's disease (AD) patients and ~30% of otherwise-normal elderly people. APOE epsilon 4 is a major risk factor for CAA in AD. Neurons are probably the source of the vascular Abeta. CAA develops when Abeta is deposited in the vessel walls along or across which it normally passes into the CSF and bloodstream. Vascular deposition is...
Topics
- Cerebral Amyloid Angiopathy
- Genetic Predisposition to Disease
- Humans
- Risk Factors