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Article

DNA sensors to assess the effect of VKORC1 and CYP2C9 gene polymorphisms on warfarin dose requirement in Chinese patients with atrial fibrillation.

Australasian physical & engineering sciences in medicine - 1 Mar 2017

Huang Tao-Sheng, Zhang Ling, He Qiong, Li Yu-Bin, Dai Zhong-Li, Zheng Jian-Rui, Cheng Pei-Qi, He Yun-Shao

Abstract excerpt

The optimal dose of warfarin depends on polymorphisms in the VKORC1 (the vitamin K epoxide reductase complex subunit (1) and CYP2C9 (cytochrome P450 2C9) genes. To minimize the risk of adverse reactions, warfarin dosages should be adjusted according to results from rapid and simple monitoring methods. However, there are few pharmacogenetic-guided warfarin dosing algorithms that are based on large cohorts from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28083852
DOI: 10.1007/s13246-016-0519-x

Genes

VKORC1

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