Article
A fully integrated and automated microsystem for rapid pharmacogenetic typing of multiple warfarin-related single-nucleotide polymorphisms.
Lab on a chip - 7 Jan 2016
Zhuang Bin, Han Junping, Xiang Guangxin, Gan Wupeng, Wang Shuaiqin, Wang Dong, Wang Lei, Sun Jing, Li Cai-Xia, Liu Peng
Abstract excerpt
A fully integrated and automated microsystem consisting of low-cost, disposable plastic chips for DNA extraction and PCR amplification combined with a reusable glass capillary array electrophoresis chip in a modular-based format was successfully developed for warfarin pharmacogenetic testing. DNA extraction was performed by adopting a filter paper-based method, followed by "in situ" PCR that was carried out...
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