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Article

A new nested allele-specific multiplex polymerase chain reaction method for haplotyping of VKORC1 gene to predict warfarin sensitivity.

BioMed research international - 1 Jan 2014

Chua Yung An, Abdullah Wan Zaidah, Yusof Zukurnai, Gan Siew Hua

Abstract excerpt

The vitamin K epoxide reductase complex 1 gene (VKORC1) is commonly assessed to predict warfarin sensitivity. In this study, a new nested allele-specific multiplex polymerase chain reaction (PCR) method that can simultaneously identify single nucleotide polymorphisms (SNPs) at VKORC1 381, 861, 5808, and 9041 for haplotype analysis was developed and validated. Extracted DNA was amplified in the first PCR DNA,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24790995
DOI: 10.1155/2014/316310
PMCID: PMC3985146

Genes

VKORC1

Provenance

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