Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers.

doi:10.1371/journal.pone.0246067

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Article

Priapism in sickle cell disease: Associations between NOS3 and EDN1 genetic polymorphisms and laboratory biomarkers.

PloS one - 1 Jan 2021

Figueiredo Camylla Vilas Boas, Santiago Rayra Pereira, da Guarda Caroline Conceição, Oliveira Rodrigo Mota, Fiuza Luciana Magalhães, Yahouédéhou Sètondji Cocou Modeste Alexandre, Carvalho Suéllen Pinheiro, Neres Joelma Santana Dos Santos, Oliveira Antonio Mateus de Jesus, Fonseca Cleverson Alves, Nascimento Valma Maria Lopes, Lyra Isa Menezes, Aleluia Milena Magalhães, Goncalves Marilda Souza

Abstract excerpt

Priapism is a urologic emergency characterized by an uncontrolled, persistent and painful erection in the absence of sexual stimulation, which can lead to penile fibrosis and impotence. It is highly frequent in sickle cell disease (SCD) associated with hemolytic episodes. Our aim was to investigate molecules that may participate in the regulation of vascular tone. Eighty eight individuals with SCD were included,...

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PMID: 33539452
DOI: 10.1371/journal.pone.0246067
PMCID: PMC7861393

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