Article
Alpha thalassemia, but not βS-globin haplotypes, influence sickle cell anemia clinical outcome in a large, single-center Brazilian cohort.
Annals of hematology - 1 Apr 2021
Hatzlhofer Betânia Lucena Domingues, Pereira-Martins Diego Antonio, de Farias Domingos Igor, Arcanjo Gabriela da Silva, Weinhäuser Isabel, Falcão Diego Arruda, Farias Isabela Cristina Cordeiro, de Freitas Batista Jéssica Vitória Gadelha, Prado Luana Priscilla Laranjeira, Oliveira Jéssica Maria Florencio, Batista Thais Helena Chaves, Sobreira Marcondes José de Vasconcelos Costa, de Santana Rodrigo Marcionilo, Araújo Amanda Bezerra de Sá, de Melo Manuela Albuquerque, de Ancântara Bruna Vasconcelos, Coelho-Silva Juan Luiz, de Moura Rafael Ana Beatriz Lucas, de Lima Silva Danízia Menezes, Albuquerque Flávia Peixoto, Santos Magnun Nueldo Nunes, Dos Anjos Ana Cláudia, Costa Fernando Ferreira, da Silva Araújo Aderson, Lucena-Araújo Antonio Roberto, Bezerra Marcos André Cavalcanti
Abstract excerpt
Alpha thalassemia and beta-globin haplotype are considered classical genetic disease modifiers in sickle cell anemia (SCA) causing clinical heterogeneity. Nevertheless, their functional impact on SCA disease emergence and progression remains elusive. To better understand the role of alpha thalassemia and beta-globin haplotype in SCA, we performed a retrospective study evaluating the clinical manifestations of 614...
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