Article
Influence of rs1042713 and rs1042714 polymorphisms of β2-adrenergic receptor gene with erythrocyte cAMP in sickle cell disease patients from Odisha State, India.
Annals of hematology - 1 Dec 2020
Sinha Shalini, Jit Bimal Prasad, Patro A Raj Kumar, Ray Aisurya, Dehury Snehadhini, Sahoo Sarmila, Behera Rajendra Kumar, Mohanty Pradeep Kumar, Panigrahi Pinaki, Das Padmalaya
Abstract excerpt
The vaso-occlusive crisis (VOCs) in sickle cell disease (SCD) is often associated with stress. Epinephrine released during stress acts via beta 2-adrenergic receptors (β2-AR or ADRB2) to stimulate the synthesis of cyclic adenosine monophosphate (cAMP) in the red blood cells (RBCs). Higher cAMP levels promote adhesion of sickled RBCs to vascular endothelium, a major contributor for VOCs. Several single-nucleotide...
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