Article
Comparative analysis of Hoxa5 allelic series.
Genesis (New York, N.Y. : 2000) - 1 Apr 2007
Tabariès Sébastien, Lemieux Margot, Aubin Josée, Jeannotte Lucie
Abstract excerpt
Analysis of the Hoxa5(-/-) mutants has revealed the critical role of Hoxa5 in survival, specification of axial identity, and ontogeny of organs, including the respiratory tract. The presence of the selection cassette in the original Hoxa5(-/-) mutation may interfere with the interpretation of the phenotypes. To circumvent this aspect and to bypass the lethality of the Hoxa5 mutation, we have designed a...
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