Article
HOXA5 plays tissue-specific roles in the developing respiratory system.
Development (Cambridge, England) - 1 Oct 2017
Landry-Truchon Kim, Houde Nicolas, Boucherat Olivier, Joncas France-Hélène, Dasen Jeremy S, Philippidou Polyxeni, Mansfield Jennifer H, Jeannotte Lucie
Abstract excerpt
Hoxa5 is essential for development of several organs and tissues. In the respiratory system, loss of Hoxa5 function causes neonatal death due to respiratory distress. Expression of HOXA5 protein in mesenchyme of the respiratory tract and in phrenic motor neurons of the central nervous system led us to address the individual contribution of these Hoxa5 expression domains using a conditional gene targeting...
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