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Article

An RNA-seq protocol to identify mRNA expression changes in mouse diaphyseal bone: applications in mice with bone property altering Lrp5 mutations.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Oct 2013

Ayturk Ugur M, Jacobsen Christina M, Christodoulou Danos C, Gorham Joshua, Seidman Jonathan G, Seidman Christine E, Robling Alexander G, Warman Matthew L

Abstract excerpt

Loss-of-function and certain missense mutations in the Wnt coreceptor low-density lipoprotein receptor-related protein 5 (LRP5) significantly decrease or increase bone mass, respectively. These human skeletal phenotypes have been recapitulated in mice harboring Lrp5 knockout and knock-in mutations. We hypothesized that measuring mRNA expression in diaphyseal bone from mice with Lrp5 wild-type (Lrp5(+/+) ),...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23553928
DOI: 10.1002/jbmr.1946
PMCID: PMC3743099

Genes

LRP5
HBM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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