Pharmacogenomic landscape of the Thai population from genome sequencing of 949 individuals.

doi:10.1038/s41598-024-79018-6

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Pharmacogenomic landscape of the Thai population from genome sequencing of 949 individuals.

Scientific reports - 28 Dec 2024

Piriyapongsa Jittima, Chumnumwat Supatat, Kaewprommal Pavita, Triparn Kwankom, Suvichapanich Supharat, Udomsinprasert Wanvisa, Jittikoon Jiraphun, Shaw Philip J, Nakhonsri Vorthunju, Ngamphiw Chumpol, Wangkumhang Pongsakorn, Pithukpakorn Manop, Roothumnong Ekkapong, Wiboonthanasarn Supakit, Kuptanon Chulaluck, Jinawath Natini, Porntaveetus Thantrira, Suriyaphol Prapat, Viprakasit Vip, Pisitkun Prapaporn, Kantaputra Piranit, Tim-Aroon Thipwimol, Wattanasirichaigoon Duangrurdee, Sura Thanyachai, Suphapeetiporn Kanya, Sripichai Orapan, Khongphatthanayothin Apichai, Fucharoen Suthat, Ngamphaiboon Nuttapong, Shotelersuk Vorasuk, Mahasirimongkol Surakameth, Tongsima Sissades

Abstract excerpt

Inter-individual variability in drug responses is significantly influenced by genetic factors, underscoring the importance of population-specific pharmacogenomic studies to optimize clinical outcomes. In this study, we analyzed whole genome sequencing data from 949 unrelated Thai individuals and conducted an in-depth analysis of 3239 genes involved in drug pharmacokinetics, pharmacodynamics, or immune-mediated...

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PMID: 39730427
DOI: 10.1038/s41598-024-79018-6
PMCID: PMC11681108

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