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A comprehensive Thai pharmacogenomics database (TPGxD-1): Phenotype prediction and variants identification in 942 whole-genome sequencing data.

Clinical and translational science - 1 Jun 2024

John Shobana, Klumsathian Sommon, Own-Eium Paravee, Eu-Ahsunthornwattana Jakris, Sura Thanyachai, Dejsuphong Donniphat, Sritara Piyamitr, Vathesatogkit Prin, Thongchompoo Nartthawee, Thabthimthong Wiphaporn, Teerakulkittipong Nuttinee, Chantratita Wasun, Sukasem Chonlaphat

Abstract excerpt

Computational methods analyze genomic data to identify genetic variants linked to drug responses, thereby guiding personalized medicine. This study analyzed 942 whole-genome sequences from the Electricity Generating Authority of Thailand (EGAT) cohort to establish a population-specific pharmacogenomic database (TPGxD-1) in the Thai population. Sentieon (version 201808.08) implemented the GATK best workflow...

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Identifiers

PMID: 38853370
DOI: 10.1111/cts.13830
PMCID: PMC11163017

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