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Targeted Next-Generation Sequencing for Comprehensive Genetic Profiling of Pharmacogenes.

Clinical pharmacology and therapeutics - 1 Mar 2017

Han S M, Park J, Lee J H, Lee S S, Kim H, Han H, Kim Y, Yi S, Cho J-Y, Jang I-J, Lee M G

Abstract excerpt

Phenotypic differences in drug responses have been associated with known pharmacogenomic loci, but many remain to be characterized. Therefore, we developed next-generation sequencing (NGS) panels to enable broad and unbiased inspection of genes that are involved in pharmacokinetics (PKs) and pharmacodynamics (PDs). These panels feature repetitively optimized probes to capture up to 114 PK/PD-related genes with...

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PMID: 27727443
DOI: 10.1002/cpt.532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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