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Article

Ribosome engineering of Myxococcus xanthus for enhancing the heterologous production of epothilones.

Microbial cell factories - 27 Dec 2024

Kang Xu, Yue Xiao-Ran, Wang Chen-Xi, Wang Jia-Rui, Zhao Jun-Ning, Yang Zhao-Peng, Fu Qin-Ke, Wu Chang-Sheng, Hu Wei, Li Yue-Zhong, Yue Xin-Jing

Abstract excerpt

BACKGROUND: Ribosome engineering is a semi-empirical technique used to select antibiotic-resistant mutants that exhibit altered secondary metabolism. This method has been demonstrated to effectively select mutants with enhanced synthesis of natural products in many bacterial species, including actinomycetes. Myxobacteria are recognized as fascinating producers of natural active products. However, it remains...

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PMID: 39725983
DOI: 10.1186/s12934-024-02627-3
PMCID: PMC11673899

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