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Yield improvement of enediyne yangpumicins in Micromonospora yangpuensis through ribosome engineering and fermentation optimization

2021-05-24

Abstract excerpt

Yangpumicins (YPMs), eg. YPM A, F, and G, are newly discovered enediynes from Micromonospora yangpuensis DSM 45577, which could be exploited as promising payloads of antibody-drug conjugates. However, the low yield of YPMs in the wild-type strain (~1 mg/L) significantly hampers their further drug development. In this study, a combined ribosome engineering and fermentation optimization strategy has been used for yi...

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Literature Corpus work: 7a7fe8ce-0268-5627-b141-3648f4cbc5ff
DOI: 10.22541/au.162187270.04450925/v1

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