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Article

Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234.

Journal of industrial microbiology & biotechnology - 1 Mar 2018

Liu Ling, Pan Jian, Wang Zilong, Yan Xiaohui, Yang Dong, Zhu Xiangcheng, Shen Ben, Duan Yanwen, Huang Yong

Abstract excerpt

Tiancimycin (TNM) A, a recently discovered enediyne natural product from Streptomyces sp. CB03234, showed rapid and complete killing of cancer cells and could be used as a payload in antibody drug conjugates. The low yield of TNM A in the wild-type strain promoted us to use ribosome engineering and fermentation optimization for its yield improvement. The Streptomyces sp. CB03234-R-16 mutant strain with a L422P...

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Identifiers

PMID: 29396746
DOI: 10.1007/s10295-018-2014-8
PMCID: PMC6211294

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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