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Article

Heterologous expression of epothilone biosynthetic genes in Myxococcus xanthus.

Antimicrobial agents and chemotherapy - 1 Sept 2002

Julien Bryan, Shah Sanjay

Abstract excerpt

Epothilones are potential anticancer drugs that stabilize microtubules in a manner similar to paclitaxel (Taxol). Epothilones are produced from the myxobacterium Sorangium cellulosum, which has a 16-h doubling time and produces only milligram-per-liter amounts of epothilone A and epothilone B. Furthermore, genetic manipulation of S. cellulosum is difficult. To produce epothilones in a more genetically amenable...

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Identifiers

PMID: 12183227
DOI: 10.1128/AAC.46.9.2772-2778.2002
PMCID: PMC127399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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