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Article

Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvus.

Chembiochem : a European journal of chemical biology - 13 Apr 2015

Sahner J Henning, Sucipto Hilda, Wenzel Silke C, Groh Matthias, Hartmann Rolf W, Müller Rolf

Abstract excerpt

Myxopyronin is a natural α-pyrone antibiotic from the soil bacterium Myxococcus fulvus Mx f50. Myxopyronin inhibits bacterial RNA polymerase (RNAP) by binding to a part of the enzyme not targeted by the clinically used rifamycins. This mode of action makes myxopyronins promising molecules for the development of novel broad-spectrum antibacterials. We describe the derivatization of myxopyronins by an advanced...

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PMID: 25757034
DOI: 10.1002/cbic.201402666

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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