Article
Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up.
American journal of respiratory and critical care medicine - 15 May 2017
Gref Anna, Merid Simon K, Gruzieva Olena, Ballereau Stéphane, Becker Allan, Bellander Tom, Bergström Anna, Bossé Yohan, Bottai Matteo, Chan-Yeung Moira, Fuertes Elaine, Ierodiakonou Despo, Jiang Ruiwei, Joly Stéphane, Jones Meaghan, Kobor Michael S, Korek Michal, Kozyrskyj Anita L, Kumar Ashish, Lemonnier Nathanaël, MacIntyre Elaina, Ménard Camille, Nickle David, Obeidat Ma'en, Pellet Johann, Standl Marie, Sääf Annika, Söderhäll Cilla, Tiesler Carla M T, van den Berge Maarten, Vonk Judith M, Vora Hita, Xu Cheng-Jian, Antó Josep M, Auffray Charles, Brauer Michael, Bousquet Jean, Brunekreef Bert, Gauderman W James, Heinrich Joachim, Kere Juha, Koppelman Gerard H, Postma Dirkje, Carlsten Christopher, Pershagen Göran, Melén Erik
Abstract excerpt
RATIONALE: The evidence supporting an association between traffic-related air pollution exposure and incident childhood asthma is inconsistent and may depend on genetic factors. OBJECTIVES: To identify gene-environment interaction effects on childhood asthma using genome-wide single-nucleotide polymorphism (SNP) data and air pollution exposure. Identified loci were further analyzed at epigenetic and...
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