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Article

Peptide-guided resiquimod-loaded lignin nanoparticles convert tumor-associated macrophages from M2 to M1 phenotype for enhanced chemotherapy.

Acta biomaterialia - 1 Oct 2021

Figueiredo Patrícia, Lepland Anni, Scodeller Pablo, Fontana Flavia, Torrieri Giulia, Tiboni Mattia, Shahbazi Mohammad-Ali, Casettari Luca, Kostiainen Mauri A, Hirvonen Jouni, Teesalu Tambet, Santos Hélder A

Abstract excerpt

Nanomedicines represent innovative and promising alternative technologies to improve the therapeutic effects of different drugs for cancer ablation. Targeting M2-like tumor-associated macrophages (TAMs) has emerged as a favorable therapeutic approach to fight against cancer through the modulation of the tumor microenvironment. However, the immunomodulatory molecules used for this purpose present side effects upon...

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PMID: 33011297
DOI: 10.1016/j.actbio.2020.09.038

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