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Positive regulation of a LuxR family protein, MilO, in mildiomycin biosynthesis

23 Dec 2024

Abstract excerpt

ABSTRACT Mildiomycin is a representative peptidyl nucleoside antibiotic and was first isolated from Streptoverticillium rimofaciens , which has been used as an important biological agent to control powdery mildew in plants. Despite its importance, the biosynthetic pathways and regulatory mechanisms remain to be fully elucidated. In this study, we identified MilO as a positive pathway-specific regulator of...

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PMID: 39714196
DOI: 10.1128/aem.01654-24

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