Phenotypic heterogeneity shapes phage resistance and cocktail efficacy in Klebsiella pneumoniae.

Abstract excerpt

The emergence of phage-resistant bacteria poses a significant challenge to the success of phage therapy. Although phage cocktails can delay resistance, their efficacy relies on the ability to target the full spectrum of resistant variants, which are often more diverse than those represented by clonal isolates. In this study, we investigated how phenotypic diversity within phage-resistant Klebsiella pneumoniae...

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