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Phage resistance in Klebsiella pneumoniae and bidirectional effects impacting antibiotic susceptibility.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases - 1 Jun 2024

Nang Sue C, Lu Jing, Yu Heidi H, Wickremasinghe Hasini, Azad Mohammad A K, Han Meiling, Zhao Jinxin, Rao Gauri, Bergen Phillip J, Velkov Tony, Sherry Norelle, McCarthy David T, Aslam Saima, Schooley Robert T, Howden Benjamin P, Barr Jeremy J, Zhu Yan, Li Jian

Abstract excerpt

OBJECTIVES: Bacteriophage (phage) therapy is a promising anti-infective option to combat antimicrobial resistance. However, the clinical utilization of phage therapy has been severely compromised by the potential emergence of phage resistance. Although certain phage resistance mechanisms can restore bacterial susceptibility to certain antibiotics, a lack of knowledge of phage resistance mechanisms hinders optimal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 38522841
DOI: 10.1016/j.cmi.2024.03.015

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