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Article

Investigation of the therapeutic efficacy and resistance mechanisms of lytic phages targeting ST218 KL57 CR-hvKP.

mSystems - 17 Feb 2026

Dou Liuqing, Li Jiayang, Wu Wenqi, Xu Li, Qiu Mingjie, Yang Shuanghong, Wang Jiajie, Tian Sai, Zhou Zhitao, Wu Meilin, Zhao Yun, Wu Xiuwen, Ren Jianan

Abstract excerpt

Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKP) infection is gradually increasing globally. Phage therapy is a viable application as an alternative to antibiotics. However, clinical application of phage therapy is restricted by phage resistance. To further explore the mechanism underlying phage resistance, particularly the difference observed between in vivo and in vitro, we employed a mouse...

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Identifiers

PMID: 41543254
DOI: 10.1128/msystems.01476-25
PMCID: PMC12911405

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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