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Article

Characterization of a Klebsiella pneumoniae mutant strain wGF 1-2 with attenuated virulence, altered morphology, and reduced biofilm formation.

Frontiers in cellular and infection microbiology - 1 Jan 2026

Dai Zongmao, Hu Yue, Tai Anran, Lu Yabin, Hu Shixiong, Pan Juan, Xiao Ying, Ma Xuelian, Fu Qiang, Zhao Hongqiong, Su Zhanqiang, Tong Panpan, Hao Zhihui, Yao Gang, Wang Jinquan

Abstract excerpt

Introduction: The global rise of antimicrobial resistance has positioned multidrug-resistant Klebsiella pneumoniae as a critical health threat, necessitating alternative therapeutic strategies such as phage therapy. However, the long-term evolutionary consequences of phage-bacteria interactions remain poorly understood. This study characterizes a unique attenuated mutant, wGF 1-2, derived from a hypervirulent K....

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Identifiers

PMID: 41969653
DOI: 10.3389/fcimb.2026.1761564
PMCID: PMC13066129

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