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Article

Phenotypic heterogeneity and genetic mechanisms of phage resistance in hypervirulent carbapenem-resistant Klebsiella pneumoniae.

Virulence - 1 Dec 2026

Huang Ye, Liu Yichen, Chen Shimin, Fan Ziyue, Yan Lili, Zheng Fanglin, Wei Dandan, Liu Yang, Xu Xinping

Abstract excerpt

Phage resistance represents a major obstacle to the clinical application of phage therapy for multidrug-resistant bacterial pathogens. A comprehensive understanding of the phenotypic heterogeneity and molecular mechanisms underlying phage resistance is critical for deciphering bacterium-phage interactions and optimizing therapeutic strategies. In this study, we identified four distinct resistance phenotypes in...

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Topics

Klebsiella pneumoniae
Bacteriophages
Phenotype
Mutation
Carbapenems
Anti-Bacterial Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Klebsiella Infections

Carbapenem-Resistant Enterobacteriaceae

Virulence

Humans

Source

Open in PubMed Open full text

Identifiers

PMID: 42715012
DOI: 10.1080/21505594.2026.2732318
PMCID: PMC13577281

Provenance

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