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Article

Phage Henu12-resistant mutant derives fitness trade-offs in Shigella dysenteriae.

Microbiology spectrum - 2 Dec 2025

Gomaa Salwa E, Wang Yuhan, Li Jingjing, Cao Huiru, Shen Jiawen, Dong Xiaotao, Liu Yangyang, Chen Na, Li Qiming, Yan Zhongyi, Du Yulu, Ji Xinying, Zhao Jing, Tu Yinqiong, Teng Tieshan

Abstract excerpt

The rapid emergence of multidrug-resistant Shigella dysenteriae strains necessitates new therapeutic approaches, such as phage therapy. Phages are considered a promising adjunct to antibiotics. The rapid emergence of phage-resistant bacterial mutants represents a major challenge in clinical practice. Nevertheless, this sometimes comes with fitness trade-offs. Thus, understanding the fitness trade-offs is crucial...

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Identifiers

PMID: 41143406
DOI: 10.1128/spectrum.01150-25
PMCID: PMC12671091

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