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Article

Nucleotide levels regulate germline proliferation through modulating GLP-1/Notch signaling in C. elegans.

Genes & development - 1 Feb 2016

Chi Congwu, Ronai Diana, Than Minh T, Walker Cierra J, Sewell Aileen K, Han Min

Abstract excerpt

Animals alter their reproductive programs to accommodate changes in nutrient availability, yet the connections between known nutrient-sensing systems and reproductive programs are underexplored, and whether there is a mechanism that senses nucleotide levels to coordinate germline proliferation is unknown. We established a model system in which nucleotide metabolism is perturbed in both the nematode Caenorhabditis...

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Identifiers

PMID: 26833730
DOI: 10.1101/gad.275107.115
PMCID: PMC4743060

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