Article

Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation

2020-03-25

Abstract excerpt

The p53/p21 pathway is activated in response to cell stress. However, its role in acute lung injury has not been elucidated. Acute lung injury is associated with disruption of the alveolo-capillary barrier leading to acute respiratory distress syndrome (ARDS). Mechanical ventilation may be necessary to support gas exchange in patients with ARDS, however, high positive airway pressures can cause regional overdisten...

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Literature Corpus work: 81bd6a58-9187-50ed-a402-357b53c3b2ce
DOI: 10.1101/2020.03.24.005983

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