Oncogenic p53 induces mitotic errors in lung cancer cells by recopying DNA replication forks conferring targetable proliferation advantage

Abstract excerpt

<title>Abstract</title> <p>Oncogenic p53 mutations (Onc-p53) are frequent in lung and many other solid tumors often associated with chromosome aberrations. Why cells with Onc-p53 develop chromosomal aberrations and whether the abnormalities contribute to tumor growth remain elusive. Evidence in this communication demonstrate for the first time that replication stress induced by Onc-p53 triggers re-copying of DNA...

Topics

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• Apoptosis
• DNA Damage
• DNA Repair Mechanisms
• DNA Replication
• Genetic factors in colorectal cancer
• Genomic Instability
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

2549c216-67b7-5eb5-bc05-2207d73654b1

DOI

10.21203/rs.3.rs-7303237/v1