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Article

Basal p21 controls population heterogeneity in cycling and quiescent cell cycle states

29 Sept 2014

Abstract excerpt

Phenotypic heterogeneity within a population of genetically identical cells is emerging as a common theme in multiple biological systems, including human cell biology and cancer. Using live-cell imaging, flow cytometry, and kinetic modeling, we showed that two states--quiescence and cell cycling--can coexist within an isogenic population of human cells and resulted from low basal expression levels of p21, a...

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PMID: 25267623
DOI: 10.1073/pnas.1409797111

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