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Article

A rare KLHDC4 variant Glu510Lys is associated with genetic susceptibility and promotes tumor metastasis in nasopharyngeal carcinoma.

Journal of genetics and genomics = Yi chuan xue bao - 1 Apr 2025

Cheng Xi-Xi, Lin Guo-Wang, Zhou Ya-Qing, Li Yi-Qi, He Shuai, Liu Yang, Zeng Yan-Ni, Guo Yun-Miao, Liu Shu-Qiang, Peng Wan, Wei Pan-Pan, Luo Chun-Ling, Bei Jin-Xin

Abstract excerpt

Various genetic association studies have identified numerous single nucleotide polymorphisms (SNPs) associated with nasopharyngeal carcinoma (NPC) risk. However, these studies have predominantly focused on common variants, leaving the contribution of rare variants to the "missing heritability" largely unexplored. Here, we integrate genotyping data from 3925 NPC cases and 15,048 healthy controls to identify a rare...

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Identifiers

PMID: 39706520
DOI: 10.1016/j.jgg.2024.12.008

Genes

KLHDC4

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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