Article
Previously reported CCDC26 risk variant and novel germline variants in GALNT13, AR, and MYO10 associated with familial glioma in Finland.
Scientific reports - 21 May 2024
Nurminen Riikka, Afyounian Ebrahim, Paunu Niina, Katainen Riku, Isomäki Mari, Nurminen Anssi, Scaravilli Mauro, Tolppanen Jenni, Fey Vidal, Kivinen Anni, Helén Pauli, Välimäki Niko, Kesseli Juha, Aaltonen Lauri A, Haapasalo Hannu, Nykter Matti, Rautajoki Kirsi J
Abstract excerpt
Predisposing factors underlying familial aggregation of non-syndromic gliomas are still to be uncovered. Whole-exome sequencing was performed in four Finnish families with brain tumors to identify rare predisposing variants. A total of 417 detected exome variants and 102 previously reported glioma-related variants were further genotyped in 19 Finnish families with brain tumors using targeted sequencing. Rare...
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