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Molecular Pathway Analysis of Mutation Data for Biomarkers Discovery and Scoring of Target Cancer Drugs.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2020

Zolotovskaia Marianna, Sorokin Maxim, Garazha Andrew, Borisov Nikolay, Buzdin Anton

Abstract excerpt

DNA mutations govern cancer development. Cancer mutation profiles vary dramatically among the individuals. In some cases, they may serve as the predictors of disease progression and response to therapies. However, the biomarker potential of cancer mutations can be dramatically (several orders of magnitude) enhanced by applying molecular pathway-based approach. We developed Oncobox system for calculation of...

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PMID: 31667773
DOI: 10.1007/978-1-0716-0138-9_16

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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