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Article

A novel pathway mutation perturbation score predicts the clinical outcomes of immunotherapy.

Briefings in bioinformatics - 20 Sept 2022

Li Xiangmei, He Yalan, Wu Jiashuo, Qiu Jiayue, Li Ji, Wang Qian, Jiang Ying, Han Junwei

Abstract excerpt

The link between tumor genetic variations and immunotherapy benefits has been widely recognized. Recent studies suggested that the key biological pathways activated by accumulated genetic mutations may act as an effective biomarker for predicting the efficacy of immune checkpoint inhibitor (ICI) therapy. Here, we developed a novel individual Pathway Mutation Perturbation (iPMP) method that measures the pathway...

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PMID: 36063561
DOI: 10.1093/bib/bbac360

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