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Article

Biomarker-guided clustering of Alzheimer's disease clinical syndromes

10 Sept 2019

Abstract excerpt

Alzheimer's disease (AD) neuropathology is extremely heterogeneous, and the evolution from preclinical to mild cognitive impairment until dementia is driven by interacting genetic/biological mechanisms not fully captured by current clinical/research criteria. We characterized the heterogeneous “construct” of AD through a cerebrospinal fluid biomarker-guided stratification approach. We analyzed 5 validated...

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PMID: 31585366
DOI: 10.1016/j.neurobiolaging.2019.08.032

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