Article

Genome-wide analyses reveal shared and distinct genetic architecture linking amyotrophic lateral sclerosis, sporadic frontotemporal dementia and cognitive traits

2026-08-19

Abstract excerpt

Cognitive and behavioural impairment frequently accompanies motor decline in amyotrophic lateral sclerosis (ALS), with 15% of cases meeting the diagnostic criteria for frontotemporal dementia (FTD). We mapped the shared genetic architecture of ALS, sporadic FTD (sFTD) and cognitive traits using genome-wide association data. Pleiotropy mapping and colocalisation highlighted 26 loci shared between ALS and cognitive...

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Literature Corpus work: 5f8419ae-ea23-52d8-9b48-05d8b71a6949
DOI: 10.64898/2026.08.17.26360494

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