Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells.

Fluids and barriers of the CNS - 18 Nov 2024

Peltonen Sanni, Sonninen Tuuli-Maria, Niskanen Jonna, Koistinaho Jari, Ruponen Marika, Lehtonen Šárka

Abstract excerpt

BACKGROUND: Pericytes play a crucial role in controlling inflammation and vascular functions in the central nervous system, which are disrupted in Parkinson's disease (PD). Still, there is a lack of studies on the impact of pericytes on neurodegenerative diseases, and their involvement in the pathology of PD is unclear. Our objective was to investigate the molecular and functional differences between healthy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Movement
Share to Cells, Cultured

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Induced Pluripotent Stem Cells

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Mutation

Share to Parkinson Disease

Share to Pericytes

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 39551752
DOI: 10.1186/s12987-024-00592-y
PMCID: PMC11571670

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutated LRRK2 induces a reactive phenotype and alters migration in human iPSC-derived pericyte-like cells.PMID 39551752Read ↗

Human iPSC-derived pericyte-like cells carrying the LRRK2 mutation induce a reactive phenotype and alter migrationSemantic proximity Read ↗

LRRK2 G2019S Mutated iPSC-Derived Endothelial Cells Exhibit Increased α-Synuclein, Mitochondrial Impairment, and Altered Inflammatory Responses.Semantic proximity Read ↗

LRRK2 G2019S Mutation Affects Human iPSC-Derived Endothelial CellsSemantic proximity Read ↗

Increased peripheral inflammation in asymptomatic leucine‐rich repeat kinase 2 mutation carriersSemantic proximity Read ↗

LRRK2 links genetic and sporadic Parkinson's diseaseSemantic proximity Read ↗

Multiple-Hit Hypothesis in Parkinson’s Disease: LRRK2 and InflammationSemantic proximity Read ↗

Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain.Semantic proximity Read ↗

LRRK2 G2019S and Parkinson's disease: insight from Neuroinflammation.Semantic proximity Read ↗

Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation.Semantic proximity Read ↗

Molecular mechanisms underlying therapeutic potential of pericytesSemantic proximity Read ↗

LRRK2 as a target for modulating immune system responses.Semantic proximity Read ↗

Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.