Article
A scalable embryonic stem cell-based platform for efficient generation of mitochondrial DNA mutant mice.
Proceedings of the National Academy of Sciences of the United States of America - 14 Apr 2026
Fan Weiwei, Oh Tae Gyu, Crossley Lillian, Robbins Hunter, He Mingxiao, Dai Yang, Truitt Morgan L, Atkins Annette R, Downes Michael, Evans Ronald M
Abstract excerpt
Mitochondria are central to energy metabolism and cellular signaling, and mutations in mitochondrial DNA (mtDNA) can disrupt these processes and contribute to human disease. However, progress in defining how mtDNA variation influences adaptation, pathophysiology, and disease susceptibility has been limited by the lack of suitable animal models. Although recent base-editing approaches enable direct mtDNA...
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