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Hallmarks and mechanisms of cellular senescence in aging and disease

4 Aug 2025

Abstract excerpt

Cellular senescence, often referred to simply as "senescence", is a complex intracellular process with diverse biological, physiological, and pathological roles. Biologically, it is essential for embryogenesis and development. Physiologically, senescence acts as a safeguard against tumorigenesis by preventing the proliferation of damaged or defective cells. However, persistent activation of senescence can...

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PMID: 40759632
DOI: 10.1038/s41420-025-02655-x

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