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Article

Cellular senescence in ageing: from mechanisms to therapeutic opportunities.

Nature reviews. Molecular cell biology - 1 Feb 2021

Di Micco Raffaella, Krizhanovsky Valery, Baker Darren, d'Adda di Fagagna Fabrizio

Abstract excerpt

Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions. Eminently characterized by a permanent proliferation arrest, cellular senescence occurs in response to endogenous and exogenous stresses, including telomere dysfunction, oncogene activation and persistent DNA damage. Cellular senescence can also be a...

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Identifiers

PMID: 33328614
DOI: 10.1038/s41580-020-00314-w
PMCID: PMC8344376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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