Article
Cellular senescence in ageing: from mechanisms to therapeutic opportunities.
Nature reviews. Molecular cell biology - 1 Feb 2021
Di Micco Raffaella, Krizhanovsky Valery, Baker Darren, d'Adda di Fagagna Fabrizio
Abstract excerpt
Cellular senescence, first described in vitro in 1961, has become a focus for biotech companies that target it to ameliorate a variety of human conditions. Eminently characterized by a permanent proliferation arrest, cellular senescence occurs in response to endogenous and exogenous stresses, including telomere dysfunction, oncogene activation and persistent DNA damage. Cellular senescence can also be a...
Topics
- Aging
- Animals
- Cell Proliferation
- Cellular Senescence
- DNA Damage
- Humans
- Phenotype
- Telomere
- Translational Research, Biomedical