Genome-Wide European Ancestry Study Identifies Coronary Artery Disease-Associated Loci Through Gene-Sex Hormone Interaction.

doi:10.1161/JAHA.123.034132

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Article

Genome-Wide European Ancestry Study Identifies Coronary Artery Disease-Associated Loci Through Gene-Sex Hormone Interaction.

Journal of the American Heart Association - 17 Dec 2024

Jain Vardhmaan, Dabbs-Brown Amonae, Liu Chang, Hui Qin, Mehta Anurag, Wilson Peter W F, Quyyumi Arshed A, Sun Yan V

Abstract excerpt

BACKGROUND: Although sex differences in coronary artery disease (CAD) risk have been observed, little is known about the role of sex hormones in CAD genetics. Accounting for sex hormone levels may help identify CAD-risk loci and extend our knowledge of its genetic architecture. METHODS AND RESULTS: A total of 365 662 individuals of European ancestry enrolled in the UK Biobank were considered. Genetic interaction...

Topics

Humans
Coronary Artery Disease
Genome-Wide Association Study
Male
Female
White People
Middle Aged
Polymorphism, Single Nucleotide
Genetic Predisposition to Disease
Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Testosterone

Sex Hormone-Binding Globulin

Sex Factors

Gene-Environment Interaction

United Kingdom

Gonadal Steroid Hormones

Risk Assessment

Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 39673284
DOI: 10.1161/JAHA.123.034132
PMCID: PMC11935546

Genes

CAD
SHBG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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