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Sexual Differences in Genetic Predisposition of Coronary Artery Disease.

Circulation. Genomic and precision medicine - 1 Feb 2021

Huang Yunfeng, Hui Qin, Gwinn Marta, Hu Yi-Juan, Quyyumi Arshed A, Vaccarino Viola, Sun Yan V

Abstract excerpt

BACKGROUND: The genomic structure that contributes to the risk of coronary artery disease (CAD) can be evaluated as a risk score of multiple variants. However, sex differences have not been fully examined in applications of genetic risk score (GRS) of CAD. METHODS: Using data from the UK Biobank, we constructed a CAD-GRS based on all known loci, 3 mediating trait-based (blood pressure, lipids, and body mass...

Topics

Aged
Blood Pressure
Body Mass Index
Coronary Artery Disease
Female
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Male
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multifactorial Inheritance

Proportional Hazards Models

Risk Factors

Sex Characteristics

Source

Open in PubMed Open full text

Identifiers

PMID: 33332181
DOI: 10.1161/CIRCGEN.120.003147
PMCID: PMC7887043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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