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Article

Contribution of intact viral genomes persisting in blood and tissues during ART to plasma viral rebound in SHIV-infected rhesus macaques

11 Feb 2025

Abstract excerpt

Persistent SIV/HIV reservoirs are the primary obstacle to a cure and the source of viral rebound after ART interruption (ATI). However, the anatomical source of viral rebound remains elusive. Here, we characterized the proviral landscape in the blood, inguinal, and axillary lymph nodes and colon biopsies of five SHIV-infected rhesus macaques (RMs), under ART for 28 weeks. From the 144 near full-length (NFL)...

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Herpesvirus Infections and Treatments
HIV Research and Treatment
Virology and Viral Diseases

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40104070
DOI: 10.1016/j.isci.2025.111998

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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